Marcadores tumorales y su valor en ginecología
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Date
Subject
Gynecology
tumor markers
biomarkers
ginecología
marcadores tumorales
biomarcadores
tumor markers
biomarkers
ginecología
marcadores tumorales
biomarcadores
Language:
Journal Title
Journal ISSN
Volume Title
Publisher
Intituto Tecnológico de Santo Domingo (INTEC)
Los marcadores tumorales (MT) son moléculas que pueden estar elevadas en presencia de un cáncer, bien como reacción del huésped ante el tumor o bien como producto del propio tumor. Los MT no son específicos de las neoplasias, y pueden encontrarse concentraciones apreciables en un gran número de situaciones fisiológicas o patológicas tumorales. Son útiles para la detección precoz de un cáncer, para establecer el estadiaje, la respuesta a la terapia, predecir las recurrencias, presentar una elevada sensibilidad, especificidad y valor predictivo positivo y ser órgano-específicos y tumor-específicos. Dentro de los que representan más relevancia y valor en ginecología se destacan: el CEA, AFP, betaHCG, CA125, CA 15.3, CA 19.9, SCC, Citoqueratinas y LDH. Los marcadores biológicos son cambios medibles, ya sean bioquímicos, fisiológicos o morfológicos que se asocian a la exposición a algún tóxico. En las patologías oncológicas-gineco-lógicas son referidos con frecuencia los BRCA1, BCRA2 y el Her2; también pueden mencionarse: los receptores hormonales (ER y PR).
El verdadero valor clínico en ginecología reside en el segui-miento de las pacientes, tanto para detectar una recidiva temprana como para evaluar la efectividad del tratamiento. En general, los marcadores tumorales y los marcadores biológicos pueden ser la clave para reducir la mortalidad por cáncer a nivel mundial. Por lo que, nos proponemos esta revisión bibliográfica para realzar los MT más utili-zados en la práctica clínica en el área de ginecología.
Tumor markers (TM) are molecules that may be elevated in the presence of a cancer, either as a reaction of the host to the tumor or as a product of the tumor itself. TMs are not specific to neoplasms, and appreciable concen-trations can be found in a large number of physiological or pathological tumor situations. They are useful for the early detection of cancer, to establish staging, response to therapy, predict recurrences, present high sensitivity, speci-ficity and positive predictive value and be organ-specific and tumor-specific. Among those that represent more relevance and value in gynecology are: CEA, AFP, beta-HCG, CA125, CA 15.3, CA 19.9, SCC, Cytokeratins, and LDH. * Biological markers are measurable changes, whether biochemical, physiological or morphological that are associated with exposure to any toxic. In the oncolo-gical-gynecological pathologies, BRCA1, BCRA2 and Her2 are frequently referred to; They can also be mentioned: hormonal receptors (ER and PR). The true clinical value in gynecology lies in the follow-up of patients, both to detect early recurrence and to evaluate the effectiveness of the treatment. In general, tumor markers and biological markers may be the key to reducing cancer mortality worldwide. Therefore, we propose this biblio-graphic review to enhance the TM most used in clinical practice in the area of gynecology.
Tumor markers (TM) are molecules that may be elevated in the presence of a cancer, either as a reaction of the host to the tumor or as a product of the tumor itself. TMs are not specific to neoplasms, and appreciable concen-trations can be found in a large number of physiological or pathological tumor situations. They are useful for the early detection of cancer, to establish staging, response to therapy, predict recurrences, present high sensitivity, speci-ficity and positive predictive value and be organ-specific and tumor-specific. Among those that represent more relevance and value in gynecology are: CEA, AFP, beta-HCG, CA125, CA 15.3, CA 19.9, SCC, Cytokeratins, and LDH. * Biological markers are measurable changes, whether biochemical, physiological or morphological that are associated with exposure to any toxic. In the oncolo-gical-gynecological pathologies, BRCA1, BCRA2 and Her2 are frequently referred to; They can also be mentioned: hormonal receptors (ER and PR). The true clinical value in gynecology lies in the follow-up of patients, both to detect early recurrence and to evaluate the effectiveness of the treatment. In general, tumor markers and biological markers may be the key to reducing cancer mortality worldwide. Therefore, we propose this biblio-graphic review to enhance the TM most used in clinical practice in the area of gynecology.
Description
Type
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/publishedVersion
Source
Science and Health; Vol 4 No 1 (2020): Science and Health, january-april; 27-47
Ciencia y Salud; Vol. 4 Núm. 1 (2020): Ciencia y Salud, enero-abril; 27-47
2613-8824
2613-8816
10.22206/cysa.2020.v4i1
Ciencia y Salud; Vol. 4 Núm. 1 (2020): Ciencia y Salud, enero-abril; 27-47
2613-8824
2613-8816
10.22206/cysa.2020.v4i1