Intoxicación pediátrica por Paraquat: presentación de caso, Hospital Infantil Dr. Robert Reid Cabral (HIRRC), República Dominicana
Date
Subject
paraquat
herbicida
intoxicación
pulmonar fibrosis
mortality
paraquat
herbicida
intoxicación
fibrosis pulmonar
mortalidad
herbicida
intoxicación
pulmonar fibrosis
mortality
paraquat
herbicida
intoxicación
fibrosis pulmonar
mortalidad
Language:
Journal Title
Journal ISSN
Volume Title
Publisher
Intituto Tecnológico de Santo Domingo (INTEC)
Introducción: el paraquat (dicloruro de 1,1’-dimetil-4,4’-bipiridilo) es un químico tóxico utilizado mundialmente como herbicida. La etiología de la intoxicación por paraquat se debe en su mayoría a la ingestión suicida. Fisiopatológicamente, el pulmón, el hígado y el riñón son los órganos especialmente afectados por el paraquat debido a su alta saturación de oxígeno. La letalidad por intoxicación por paraquat es muy alta, cerca del 80%, siendo la fibrosis pulmonar la causa más frecuente de muerte.
Objetivos: el siguiente documento tiene la intención de identificar los principales signos y síntomas que constituyen la presentación clínica de la intoxicación por paraquat en un paciente pediátrico. A pesar de la limitada bibliografía, se pretendió hacer una comparación de la presentación y el progreso clínico con otros casos de intoxicación por paraquat.
Material y Métodos: se expone el caso clínico de una joven de 15 años, la cual ingirió aproximadamente 250 ml de paraquat con intención autolítica. La misma presentó inicialmente afección en el tracto gastrointestinal, seguido de alteración de las pruebas hepáticas, renales y pancreáticas, y dificultad respiratoria.
Conclusiones: luego de describir la presentación clínica de nuestra paciente, y de compararla con la de otros casos similares, concluimos que el diagnóstico precoz y exhaustivo de la intoxicación por paraquat reduce significativamente su mortalidad debido a la actual inexistencia de un antídoto específico para dicho envenenamiento. Asimismo, recomendamos tener siempre presente la intoxicación por paraquat al momento de recibir pacientes con la presentación característica luego de la ingesta de sustancias desconocidas.
Introduction: paraquat (1, 1’-dimethyl-4, 4’-bipyridinium dichloride) is a toxic chemical used worldwide as an herbicide. Paraquat poisoning in its vast majority is due to a suicidal ingestion. Pathophysiologically, the lung, the liver and the kidney are the specially affected organs due to their high oxygen saturation. Paraquat poisoning has a very high mortality rate, close to 80%, being pulmonary fibrosis the most common cause of death. Objetive: the following document has the intention to identify the principal signs and symptoms that constitute the clinical presentation of paraquat poisoning in a pediatric patient. Even though there is limited bibliography, we try to compare the clinical presentation and progress with other cases of paraquat poisoning. Material and Methods: we present the case of a 15 years old woman, who ingested approximately 250 ml of paraquat as a suicidal attempt. Even though there is limited bibliography, we try to compare the clinical presentation and progress with other cases of paraquat poisoning. She presented with lesions in the GI tract, followed by hepatic, renal and pancreatic alterations, and respiratory difficulty. Conclusion: after describing the clinical presentation of our patient, and comparing it with those from other similar cases, we conclude that early diagnosis and a comprehensive, exhaustive management reduces mortality due to the inexistence of a specific antidote for this poisoning. As a result, we recommend that paraquat intoxication should always be kept in mind when receiving patient with the characteristic presentation after the intake of unknown substances.
Introduction: paraquat (1, 1’-dimethyl-4, 4’-bipyridinium dichloride) is a toxic chemical used worldwide as an herbicide. Paraquat poisoning in its vast majority is due to a suicidal ingestion. Pathophysiologically, the lung, the liver and the kidney are the specially affected organs due to their high oxygen saturation. Paraquat poisoning has a very high mortality rate, close to 80%, being pulmonary fibrosis the most common cause of death. Objetive: the following document has the intention to identify the principal signs and symptoms that constitute the clinical presentation of paraquat poisoning in a pediatric patient. Even though there is limited bibliography, we try to compare the clinical presentation and progress with other cases of paraquat poisoning. Material and Methods: we present the case of a 15 years old woman, who ingested approximately 250 ml of paraquat as a suicidal attempt. Even though there is limited bibliography, we try to compare the clinical presentation and progress with other cases of paraquat poisoning. She presented with lesions in the GI tract, followed by hepatic, renal and pancreatic alterations, and respiratory difficulty. Conclusion: after describing the clinical presentation of our patient, and comparing it with those from other similar cases, we conclude that early diagnosis and a comprehensive, exhaustive management reduces mortality due to the inexistence of a specific antidote for this poisoning. As a result, we recommend that paraquat intoxication should always be kept in mind when receiving patient with the characteristic presentation after the intake of unknown substances.
Description
Type
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/publishedVersion
Source
Science and Health; Vol 3 No 1 (2019): Science and Health, january-april; 73-78
Ciencia y Salud; Vol. 3 Núm. 1 (2019): Ciencia y Salud, enero-abril; 73-78
2613-8824
2613-8816
10.22206/cysa.2019.v3i1
Ciencia y Salud; Vol. 3 Núm. 1 (2019): Ciencia y Salud, enero-abril; 73-78
2613-8824
2613-8816
10.22206/cysa.2019.v3i1