Germinoma pineal como causa de panhipopituitarismo: reporte de un caso
Date
Subject
intracranial germ cell tumor
pineal germinoma
panhypopituitarism
diabetes insipidus
hormone replacement therapy
Tumor de células germinales
germinoma pineal
panhipopituitarismo
diabetes insípida
terapia de reemplazo hormonal
pineal germinoma
panhypopituitarism
diabetes insipidus
hormone replacement therapy
Tumor de células germinales
germinoma pineal
panhipopituitarismo
diabetes insípida
terapia de reemplazo hormonal
Language:
Journal Title
Journal ISSN
Volume Title
Publisher
Intituto Tecnológico de Santo Domingo (INTEC)
Introducción: Los tumores de células germinales intracraneales constituyen un grupo infrecuente de neoplasias que afectan principalmente a la población pediátrica. Su presentación clínica varía en función de la localización y el tamaño del tumor. Las lesiones localizadas en la región pineal a menudo causan hidrocefalia obstructiva, mientras que las lesiones de localización supraselar, usualmente se asocian a disfunción del eje hipotálamo-hipofisario. Un tumor germinal de localización pineal que curse con endocrinopatías es una entidad extremadamente rara. Por tanto, reportamos el caso de un paciente masculino de 16 años de edad, con panhipopituitarismo secundario a un germinoma pineal.
Material y métodos: Este paciente fue referido al Departamento de Emergencias tras presentar hipernatremia en un análisis sanguíneo de rutina. Se presentó con polidipsia, poliuria y fatiga de un año de evolución. Las evaluaciones clínicas y pruebas de laboratorio reportaron diabetes insípida, panhipopituitarismo y hemianopsia bitemporal. El paciente recibió terapia de sustitución hormonal y tres meses después, la resonancia magnética de seguimiento reveló una masa en el área pineal que, a través de una posterior evaluación, fue diagnosticada como germinoma.
Conclusión: Luego de tratamiento con quimioterapia y radiación, hubo una resolución completa de la lesión. Sin embargo, no hubo mejoría clínica significativa y el paciente continúo necesitando terapia de reemplazo hormonal.
Introduction: Intracranial germ cell tumors are rare neoplasms primarily affecting the pediatric population. The clinical presentation varies by location and size. Lesions in the pineal region often cause obstructive hydrocephalus, while lesions in the suprasellar region typically present with hypothalamic-pituitary axis dysfunction. A pineal germ cell tumor presenting with endocrine disturbances is a extremely rare entity. One case of a sixteen-year-old male with panhypopituitarism secondary to a pineal germinoma is reported. Material and methods: This patient was referred to the emergency department after his routine laboratory values showed hypernatremia. He presented with increased thirst, polyuria, and fatigue of one-year duration. Clinical and laboratory evaluation revealed diabetes insipidus, panhypopituitarism, and bitemporal hemianopsia. He received hormone replacement therapy. Three months later, a follow-up magnetic resonance imaging revealed a mass at the pineal region diagnosed as germinoma. Conclusion: After treatment with chemotherapy and radiation, he achieved complete resolution of the lesion. However, there was no marked clinical improvement and he continued to require hormone replacement therapy.
Introduction: Intracranial germ cell tumors are rare neoplasms primarily affecting the pediatric population. The clinical presentation varies by location and size. Lesions in the pineal region often cause obstructive hydrocephalus, while lesions in the suprasellar region typically present with hypothalamic-pituitary axis dysfunction. A pineal germ cell tumor presenting with endocrine disturbances is a extremely rare entity. One case of a sixteen-year-old male with panhypopituitarism secondary to a pineal germinoma is reported. Material and methods: This patient was referred to the emergency department after his routine laboratory values showed hypernatremia. He presented with increased thirst, polyuria, and fatigue of one-year duration. Clinical and laboratory evaluation revealed diabetes insipidus, panhypopituitarism, and bitemporal hemianopsia. He received hormone replacement therapy. Three months later, a follow-up magnetic resonance imaging revealed a mass at the pineal region diagnosed as germinoma. Conclusion: After treatment with chemotherapy and radiation, he achieved complete resolution of the lesion. However, there was no marked clinical improvement and he continued to require hormone replacement therapy.
Description
Type
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/publishedVersion
Source
Science and Health; Vol 2 No 3 (2018): Science and Health, september-december; 41-46
Ciencia y Salud; Vol. 2 Núm. 3 (2018): Ciencia y Salud, septiembre-diciembre; 41-46
2613-8824
2613-8816
10.22206/cysa.2018.v2i3
Ciencia y Salud; Vol. 2 Núm. 3 (2018): Ciencia y Salud, septiembre-diciembre; 41-46
2613-8824
2613-8816
10.22206/cysa.2018.v2i3