La anosmia y su interacción en las infecciones causadas por el SARS-CoV2: una revisión
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SARS-CoV-2
Anosmia
COVID-19
review
interaction
SARS-CoV-2
anosmia
COVID-19
revisión
interacción
Anosmia
COVID-19
review
interaction
SARS-CoV-2
anosmia
COVID-19
revisión
interacción
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Volume Title
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Instituto Tecnológico de Santo Domingo (INTEC)
La anosmia es uno de los síntomas frecuentes identificados como parte del cuadro clínico de la infección por SARS-CoV2, sin embargo, los mecanismos por los cuales ocurre la disfunción olfatoria no están completamente esclarecidos. Previamente los coronavirus fueron identificados como una familia de virus que pueden causar anosmia, pero en el COVID-19, a diferencia de la familia de los rinovirus, esta no se relaciona con un proceso inflamatorio de la mucosa nasal asociado a obstrucción nasal o rinorrea, lo cual sugiere que la anosmia podría deberse a disturbios en la conducción nerviosa del estímulo olfatorio. La anosmia de los pacientes con COVID-19 recuerda en algunos aspectos al síndrome de Kallman, el cual también cursa con anosmia, su etiología es genética y se debe a mutaciones en el gen ANOS 1 que codifica la molécula de adhesión celular anosmia. En esta revisión se suministrará una recopilación de evidencias fisiopatológicas e interacciones moleculares mediante la cual la proteína anosmia podría modificar el curso de la infección por SARS-CoV2, para ello, se realizó una búsqueda computarizada de literatura para desvendar las posibles relaciones que existen en entre la anosmia y las infecciones causadas por el SARS-CoV2.
Anosmia is one of the frequent symptoms identified as part of the clinical picture of SARS-CoV2 infection. However, the mechanisms by which olfactory dysfunction occurs are not entirely clarified. Previously, coronaviruses were identified as a family of viruses that can cause anosmia. However, in COVID-19, unlike the rhinovirus family, this is not related to an inflammatory process of the nasal mucosa associated with nasal obstruction or rhinorrhea, which suggests that the anosmia could be due to disturbances in the nerve conduction of the olfactory stimulus. The anosmia of patients with COVID-19 is reminiscent of some aspects of Kallman’s syndrome, which also occurs with anosmia; its etiology is genetic and is due to mutations in the ANOS 1 gene that encodes the cell adhesion molecule anosmia. This review will provide a compilation of pathophysiological evidence and molecular interactions through which the anosmia protein could modify the course of the SARS-CoV2 infection. For this, a computerized literature search was carried out to unravel the possible relationships between anosmia and infections caused by SARS-CoV-2.
Anosmia is one of the frequent symptoms identified as part of the clinical picture of SARS-CoV2 infection. However, the mechanisms by which olfactory dysfunction occurs are not entirely clarified. Previously, coronaviruses were identified as a family of viruses that can cause anosmia. However, in COVID-19, unlike the rhinovirus family, this is not related to an inflammatory process of the nasal mucosa associated with nasal obstruction or rhinorrhea, which suggests that the anosmia could be due to disturbances in the nerve conduction of the olfactory stimulus. The anosmia of patients with COVID-19 is reminiscent of some aspects of Kallman’s syndrome, which also occurs with anosmia; its etiology is genetic and is due to mutations in the ANOS 1 gene that encodes the cell adhesion molecule anosmia. This review will provide a compilation of pathophysiological evidence and molecular interactions through which the anosmia protein could modify the course of the SARS-CoV2 infection. For this, a computerized literature search was carried out to unravel the possible relationships between anosmia and infections caused by SARS-CoV-2.
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info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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Science, Environment and Climate; Vol. 4 No. 2 (2021): Science, Environment and Climate; 7-17
Ciencia, Ambiente y Clima; Vol. 4 Núm. 2 (2021): Ciencia, Ambiente y Clima; 7-17
2636-2333
2636-2317
10.22206/cac.2021.v4i2
Ciencia, Ambiente y Clima; Vol. 4 Núm. 2 (2021): Ciencia, Ambiente y Clima; 7-17
2636-2333
2636-2317
10.22206/cac.2021.v4i2