Factores asociados a severidad y mortalidad en pacientes con COVID-19: estudio multicéntrico en República Dominicana
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Date
Subject
COVID-19
mortality
severity
risk
Dominican Republic
COVID-19
mortalidad
severidad
riesgo
República Dominicana
mortality
severity
risk
Dominican Republic
COVID-19
mortalidad
severidad
riesgo
República Dominicana
Language:
Journal Title
Journal ISSN
Volume Title
Publisher
Intituto Tecnológico de Santo Domingo (INTEC)
Objetivo: identificar factores asociados a severidad y mortalidad por COVID-19.
Material y métodos: estudio observacional multicéntrico retrospectivo de pacientes ingresados por COVID-19 en centros de una ciudad de la República Dominicana. Se reportaron datos demográficos, clínicos, terapéuticos y de laboratorio para su comparación entre pacientes con enfermedad severa y no severa, fallecidos y dados de alta.
Resultados: los factores asociados a mayor riesgo de severidad y mortalidad fueron el sexo masculino, la hipertensión arterial, la cantidad de comorbilidades, el uso de fármacos previos, niveles elevados de marcadores inflamatorios, linfopenia, neutrofilia, entre otros. Mientras que el uso de inhibidores de la enzima convertidora de angiotensina se asoció a menor mortalidad.
Conclusiones: la identificación de los factores asociados a progresión severa y mortal por COVID-19 contribuye a la toma temprana de decisiones relacionadas a la hospitalización y a pautas de manejo médico diferencial en quienes conllevan mayor riesgo de desenlaces adversos.
Objective: To identify factors associated with severity and mortality by COVID-19. Material and methods: Retrospective multicenter observational study of patients admitted with COVID-19 in health centers in a city of the Dominican Republic. Demographic, clinical, therapeutic and laboratory data were reported for comparison between patients with severe and non-severe disease, deceased and discharged. Results: Factors significantly associated with higher risk of severity and mortality were male sex, hypertension, number of comorbidities, drugs’ used previously, high levels of inflammatory markers, lymphopenia, neutrophilia, among others. While the use of angiotensin converting enzyme inhibitors was associated with lower mortality. Conclusions: Identification of factors associated with severe and fatal progression of COVID-19 contributes to early clinical decision-making related to hospitalization and differential medical management in those at increased risk of adverse outcomes.
Objective: To identify factors associated with severity and mortality by COVID-19. Material and methods: Retrospective multicenter observational study of patients admitted with COVID-19 in health centers in a city of the Dominican Republic. Demographic, clinical, therapeutic and laboratory data were reported for comparison between patients with severe and non-severe disease, deceased and discharged. Results: Factors significantly associated with higher risk of severity and mortality were male sex, hypertension, number of comorbidities, drugs’ used previously, high levels of inflammatory markers, lymphopenia, neutrophilia, among others. While the use of angiotensin converting enzyme inhibitors was associated with lower mortality. Conclusions: Identification of factors associated with severe and fatal progression of COVID-19 contributes to early clinical decision-making related to hospitalization and differential medical management in those at increased risk of adverse outcomes.
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info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/publishedVersion
Source
Science and Health; Vol. 7 No. 2 (2023): Science and Health, April-June; 17-30
Ciencia y Salud; Vol. 7 Núm. 2 (2023): Ciencia y Salud, abril-junio; 17-30
2613-8824
2613-8816
10.22206/cysa.2023.v7i2
Ciencia y Salud; Vol. 7 Núm. 2 (2023): Ciencia y Salud, abril-junio; 17-30
2613-8824
2613-8816
10.22206/cysa.2023.v7i2