Mpox (previamente Viruela del Simio) y coinfecciones con VIH en la República Dominicana: Una serie de casos
Date
Subject
Mpox
virus de la viruela del simio
VIH
República Dominicana
Mpox
monkeypox virus
HIV
Dominican Republic
virus de la viruela del simio
VIH
República Dominicana
Mpox
monkeypox virus
HIV
Dominican Republic
Language:
Journal Title
Journal ISSN
Volume Title
Publisher
Intituto Tecnológico de Santo Domingo (INTEC)
A pesar de ser endémico en regiones del África central, el virus Mpox (previamente Virus de la Viruela del Simio) no ha sido abundantemente caracterizado en países no-endémicos con la región de Latinoamerica. Esto se acentúa con co-infecciones por el VIH que escasamente se representan en la literatura cientifica actual. Aquí presentamos cinco casos clínicos de coinfecciones de Mpox y VIH, sus características clínicas y marcadores biológicos de infección (CD4:CD8).
Resultados:
La ocurrencia de manifestaciones clínicas y sus complicaciones dependen de las reacciones pro-inflamatorias inducidas por el hospedero, el tratamiento antirretroviral y el abordaje sintomatológico temprano podrían modificar las complicaciones y hospitalizaciones observadas en otros entornos no-endémicos de Mpox durnate el brote del 2022-2023. La estimulación pro-inflamatoria nos da algunas claves de qué tipo de marcadores observar durante futuros brotes de Mpox y su utilidad clínica pronóstica.
Despite being endemic in regions of Central Africa, the Mpox virus (previously Monkeypox virus) has not been extensively characterized in non-endemic countries such as those in the Latin American region. This is further accentuated by co-infections with HIV, which are scarcely represented in current scientific literature. Here, we present five clinical cases of coinfections of Mpox and HIV, their clinical characteristics, and biological infection markers (CD4:CD8). Results: The occurrence of clinical manifestations and their complications depends on the pro-inflammatory reactions induced by the host, antiretroviral treatment, and early symptomatic management, which could modify the complications and hospitalizations observed in other non-endemic Mpox environments during the 2022-2023 outbreak. Pro-inflammatory stimulation provides some clues as to what type of markers to observe during future Mpox outbreaks and their clinical prognostic utility.
Despite being endemic in regions of Central Africa, the Mpox virus (previously Monkeypox virus) has not been extensively characterized in non-endemic countries such as those in the Latin American region. This is further accentuated by co-infections with HIV, which are scarcely represented in current scientific literature. Here, we present five clinical cases of coinfections of Mpox and HIV, their clinical characteristics, and biological infection markers (CD4:CD8). Results: The occurrence of clinical manifestations and their complications depends on the pro-inflammatory reactions induced by the host, antiretroviral treatment, and early symptomatic management, which could modify the complications and hospitalizations observed in other non-endemic Mpox environments during the 2022-2023 outbreak. Pro-inflammatory stimulation provides some clues as to what type of markers to observe during future Mpox outbreaks and their clinical prognostic utility.
Description
Type
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/publishedVersion
Source
Science and Health; Vol. 9 No. 1 (2025): Science and Health, january-march; 59-66
Ciencia y Salud; Vol. 9 Núm. 1 (2025): Ciencia y Salud, enero-marzo; 59-66
2613-8824
2613-8816
10.22206/cisa.2025.v9i1
Ciencia y Salud; Vol. 9 Núm. 1 (2025): Ciencia y Salud, enero-marzo; 59-66
2613-8824
2613-8816
10.22206/cisa.2025.v9i1