Mecanismos de Acción de los Flavonoides: Propiedades Antioxidantes, Antibacterianas y Antifúngicas
Date
Subject
Flavonoids
antibiotic resistance
antibacterial mechanisms
antioxidant mechanisms
antifungal activity
Flavonoides
resistencia antibiótica
mecanismos antibacterianos
mecanismos antioxidantes
actividad antifúngica
antibiotic resistance
antibacterial mechanisms
antioxidant mechanisms
antifungal activity
Flavonoides
resistencia antibiótica
mecanismos antibacterianos
mecanismos antioxidantes
actividad antifúngica
Language:
Journal Title
Journal ISSN
Volume Title
Publisher
Instituto Tecnológico de Santo Domingo (INTEC)
Los flavonoides, un grupo diverso de compuestos polifenólicos naturales que se encuentran en fuentes como frutas y verduras, han acaparado la atención por sus actividades biológicas, incluidas las propiedades antioxidantes, antibacterianas y antifúngicas. Esta exhaustiva revisión profundiza en los mecanismos en lo que los flavonoides combaten el estrés oxidativo y dificultan el crecimiento de bacterias y hongos. En cuanto a la acción antioxidante, los flavonoides muestran su eficacia neutralizando las especies reactivas del oxígenomediante la donación de átomos de hidrógeno y electrones, aumentando la actividad de enzimas antioxidantes endógenas y quelando iones de metales de transición. Sus efectos antibacterianos se dirigen a las bacterias Gram positivas y negativas, alterando las membranas celulares, inhibiendo procesos enzimáticos clave y suprimiendo las bombas de eflujo, impidiendo el crecimiento bacteriano y causando la muerte celular. Además, los flavonoides presentan propiedades antifúngicas al interferir en la integridad de la membrana celular fúngica, alterando la biosíntesis del ergosterol y modulando vías críticas de transducción de señales, impidiendo en última instancia el crecimiento y la patogenicidad de los hongos. Este conocimiento sobre los mecanismos de los flavonoides no sólo es prometedor para el desarrollo terapéutico, sino que también inspira futuros avances en la investigación farmacológica.
Flavonoids, a diverse group of natural polyphenolic compounds found in various sources like fruits and vegetables, have garnered attention for their diverse biological activities, including antioxidant, antibacterial, and antifungal properties. This comprehensive review delves into the mechanisms through which flavonoids combat oxidative stress and hinder the growth of bacteria and fungi. In terms of antioxidative action, flavonoids showcase their efficacy by neutralizing reactive oxygen species through hydrogen atom and electron donation, augmenting endogenous antioxidant enzyme activity, and chelating transition metal ions. Their antibacterial effects target both Gram-positive and Gram-negative bacteria, disrupting cell membranes, inhibiting key enzymatic processes, and suppressing efflux pumps, collectively impeding bacterial growth, and causing cell death. Additionally, flavonoids exhibit antifungal properties by interfering with fungal cell membrane integrity, disrupting ergosterol biosynthesis, and modulating critical signal transduction pathways, ultimately hindering fungal growth and pathogenicity. This nuanced understanding of flavonoid mechanisms not only holds promise for therapeutic development but also inspires future advancements in pharmacological research.
Flavonoids, a diverse group of natural polyphenolic compounds found in various sources like fruits and vegetables, have garnered attention for their diverse biological activities, including antioxidant, antibacterial, and antifungal properties. This comprehensive review delves into the mechanisms through which flavonoids combat oxidative stress and hinder the growth of bacteria and fungi. In terms of antioxidative action, flavonoids showcase their efficacy by neutralizing reactive oxygen species through hydrogen atom and electron donation, augmenting endogenous antioxidant enzyme activity, and chelating transition metal ions. Their antibacterial effects target both Gram-positive and Gram-negative bacteria, disrupting cell membranes, inhibiting key enzymatic processes, and suppressing efflux pumps, collectively impeding bacterial growth, and causing cell death. Additionally, flavonoids exhibit antifungal properties by interfering with fungal cell membrane integrity, disrupting ergosterol biosynthesis, and modulating critical signal transduction pathways, ultimately hindering fungal growth and pathogenicity. This nuanced understanding of flavonoid mechanisms not only holds promise for therapeutic development but also inspires future advancements in pharmacological research.
Description
Type
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Artículos
info:eu-repo/semantics/publishedVersion
Artículos
Source
Science, Environment and Climate; Vol. 6 No. 2 (2023): Science, Environment and Climate; 33-66
Ciencia, Ambiente y Clima; Vol. 6 Núm. 2 (2023): Ciencia, Ambiente y Clima; 33-66
2636-2333
2636-2317
10.22206/cac.2023.v6i2
Ciencia, Ambiente y Clima; Vol. 6 Núm. 2 (2023): Ciencia, Ambiente y Clima; 33-66
2636-2333
2636-2317
10.22206/cac.2023.v6i2