Correlación entre el grado de hipertensión arterial y el índice de estrés oxidativo. Estudio de cohorte en una población de pacientes hipertensos sistémicos en República Dominicana

Simple item page
dc.creatorNúñez-Musa, R.
dc.creatorNúñez-Sellés, A. J.
dc.creatorMañón Rossi, W.
dc.creatorMarmolejos, R. Guillén
dc.creatorMartínez-Sánchez, G.
dc.date2019-07-26
dc.date.accessioned2020-09-09T19:43:54Z
dc.date.available2020-09-09T19:43:54Z
dc.descriptionIntroduction: Arterial hypertension (AHT) is one of the major burdens of disease and risk for cardiac infarction, heart failure and renal failure. It is recognized that the oxidative stress (OS) is a determining factor in the development of complications and the progress of the AHT. OS Index (OSI) in individuals with AHT and a healthy control group, was determined to assess their possible correlation Methods: OSI was measured in a population of 112 individuals with AHT of different levels between 50 and 70 years old, chosen at random and compared with the values of healthy volunteers control group with the aim of defining the degree of correlation between the levels of the OSI and the AHT severity, by measuring biomarkers for OS in a red cell lysate. Discussion: Despite the benefits of an antioxidant therapy (AOT) have not been definitely proven, largely because the complex diseases do not depend on a single pathophysiological component, OS remains as a cornerstone in the development of complications and the worsening of the clinical pictures of many ailments. The demonstration of specific biomarkers improve the possibility of an addressed AOT. This trial showed th at the age, gender and ethnicity do not influence the OSI and that OS was severe in HTA III cases, moderate in HTA II cases and was absent in the subgroup with HTA I. Conclusions: These results suggest a relationship between levels of EO and severity of hypertension and support evidence to design new clinical trials assessing the efficacy of an adjuvant AOT in the management of HTA.en-US
dc.descriptionIntroducción: la hipertensión arterial (HTA) es una de las mayores cargas de enfermedad y riesgo para infarto cardíaco, la insuficiencia cardíaca y el fallo renal. Se reconoce que el estrés oxidativo (EO) es un determinante en el desarrollo de complicaciones y el progreso de la HTA. Se determinó el índice de EO (IEO) en individuos con HTA y en un grupo sano control, para evaluar su posible correlación. Materiales y métodos: se midió IEO en una población de 112 individuos con HTA de distintos grados entre 50 y 70 años escogidos al azar y se comparó con los valores de un grupo control de voluntarios sanos, con la intención de definir el grado de correlación entre los niveles del IEO y la severidad de HTA, mediante la medición de biomarcadores para el EO en lisado de eritrocitos. Resultados: a pesar de que los beneficios de la terapia antioxidante (TAO) no han sido definitivamente probadas, en gran parte porque las enfermedades complejas no dependen de un solo componente fisiopatogénico, el EO sigue siendo una piedra angular en el desarrollo de complicaciones y el empeoramiento de los cuadros clínicos de muchos padecimientos. La demostración de biomarcardores específicos mejora la posibilidad de una TAO dirigida. El presente ensayo demostró que la edad, el género y la etnia no influyen en el IEO y que el EO fue severo en los casos de HTA III, moderado en HTA II y estuvo ausente en el subgrupo con HTA grado I. Conclusiones: estos resultados sugieren una relación entre los niveles de EO y severidad de HTA y sustenta evidencias para diseñar nuevos ensayos clínicos que evalúen la eficacia de una TAO adyuvante en el manejo de la HTA.es-ES
dc.formatapplication/pdf
dc.formattext/html
dc.identifierhttps://revistas.intec.edu.do/index.php/cisa/article/view/1475
dc.identifier10.22206/cysa.2019.v3i2.pp17-33
dc.identifier.urihttps://repositoriobiblioteca.intec.edu.do/handle/123456789/2742
dc.languagespa
dc.publisherIntituto Tecnológico de Santo Domingo (INTEC)es-ES
dc.relationhttps://revistas.intec.edu.do/index.php/cisa/article/view/1475/2060
dc.relationhttps://revistas.intec.edu.do/index.php/cisa/article/view/1475/2050
dc.relation/*ref*/Montezano AC, Touyz RM. Oxidative stress, Noxs, and hypertension: experimental evidence and clinical controversies. Annals of medicine. 2012;44(sup1): S2-16. doi: 10.3109/07853890.2011.653393.
dc.relation/*ref*/Rodrigo R, González J, Paoletto F. The role of oxidative stress in the pathophysiology of hypertension. Hypertens Res. 2011;34(4): 431-40. doi: 10.1038/hr.2010.264.
dc.relation/*ref*/Baradaran A, Nasri H, Rafieian-Kopaei M. Oxidative stress and hypertension: Possibility of hypertension therapy with antioxidants. J Res Med Sci. 2014; 19(4): 358-67.
dc.relation/*ref*/Delbosc S, Paizanis E, Magous R, Araiz C, Dimo T, Cristol JP, Cros G, Azay J. Involvement of oxidative stress and NADPH oxidase activation in the development of cardiovascular complications in a model of insulin resistance, the fructose-fed rat. Atherosclerosis. 2005;179(1): 43-9. doi: https://doi.org/10.1016/j.atherosclerosis.2004.10.018.
dc.relation/*ref*/Niedowicz DM, Daleke DL. The role of oxidative stress in diabetic complications. Cell biochemistry and biophysics. 2005;43(2): 289-330. doi: https://doi.org/10.1385/CBB:43:2:289.
dc.relation/*ref*/Guzik TJ, Touyz RM. Oxidative stress, inflammation, and vascular aging in hypertension. Hypertension. 2017;70(4): 660-7. doi: https://doi.org/10.1161/HYPERTENSIONAHA.117.07802.
dc.relation/*ref*/Vella RK, Pullen C, Coulson FR, Fenning AS. Resveratrol prevents cardiovascular complications in the SHR/STZ rat by reductions in oxidative stress and inflammation. BioMed research international. 2015;2015: ID 918123. doi: http://dx.doi.org/10.1155/2015/918123.
dc.relation/*ref*/Lau YS, Ling WC, Dharmani Murugan MR. Boldine ameliorates vascular oxidative stress and endothelial dysfunction: Therapeutic implication for hypertension and diabetes. J Cardiovasc Pharmacol. 2015;65(6): 522-31. doi: 10.1097/FJC.0000000000000185.
dc.relation/*ref*/Sinha N, Kumar Dabla P. Oxidative stress and antioxidants in hypertension–a current review. Curr hypertens Rev. 2015;11(2):132-42. doi: 10.2174/1573402111666150529130922.
dc.relation/*ref*/Ceriello A, Testa R, Genovese S. Clinical implications of oxidative stress and potential role of natural antioxidants in diabetic vascular complications. Nutr Metab Cardiovasc Dis. 2016;26(4): 285-92. doi: 10.1016/j.numecd.2016.01.006.
dc.relation/*ref*/Pourvali K, Abbasi M, Mottaghi A. Role of superoxide dismutase 2 gene Ala16Val polymorphism and total antioxidant capacity in diabetes and its complications. Avicenna J Med Biotechnol. 2016;8(2): 48-56.
dc.relation/*ref*/Mikhak B, Hunter D J, Spiegelman D, Platz E A, Wu K, Erdman J W Jr, Giovannucci E. Manganese superoxide dismutase (MnSOD) gene polymorphism, interactions with carotenoid levels and prostate cancer risk. Carcinogenesis. 2008;29(12): 2335-40. doi:10.1093/carcin/bgn212.
dc.relation/*ref*/Martins Gregório B, Benchimol De Souza D, Amorim de Morais Nascimento F, Matta L, Fernandes-Santos C. The potential role of antioxidants in metabolic syndrome. Current pharmaceutical design. 2016;22(7): 859-69. doi: https://doi.org/10.1155/2017/3279061.
dc.relation/*ref*/Putri AY, Thaha M. Role of oxidative stress on chronic kidney disease progression. Acta Med Indones. 2016;46(3): 244-52.
dc.relation/*ref*/Velusamy T, Panneerselvam AS, Purushottam M, Anusuyadevi M, Pal PK, Jain S, et al. Protective effect of antioxidants on neuronal dysfunction and plasticity in Huntington’s disease. Oxidative medicine and cellular longevity. 2017;2017: ID 3279061. doi: https://doi.org/10.1155/2017/3279061.
dc.relation/*ref*/Zhang YJ, Gan RY, Li S, Zhou Y, Li AN, Xu DP, Li HB. Antioxidant phytochemicals for the prevention and treatment of chronic diseases. Molecules. 2015;20(12): 21138-56. doi: https://doi.org/10.3390/molecules201219753.
dc.relation/*ref*/Oyenihi AB, Ayeleso AO, Mukwevho E, Masola B. Antioxidant strategies in the management of diabetic neuropathy. BioMed Res Int. 2015;2015: ID 515042. doi: http://dx.doi.org/10.1155/2015/515042.
dc.relation/*ref*/Ahmad KA, Yuan Yuan D, Nawaz W, Ze H, Zhuo CX, Talal B, et al. Antioxidant therapy for management of oxidative stress induced hypertension. Free Radic Res. 2017;51(4): 428-38. doi: 10.1080/10715762.2017.1322205.
dc.relation/*ref*/Maiese K. New insights for oxidative stress and diabetes mellitus. Oxid Med Cell Longev. 2015;2015: ID 875961. doi: 10.1155/2015/875961. 20. Montezano AC, Dulak-Lis M, Tsiropoulou S, Harvey A, Briones AM, Touyz RM. Oxidative stress and human hypertension: vascular mechanisms, biomarkers, and novel therapies. Can J Cardiol. 2015;31(5): 631-41. doi: 10.1016/j.cjca.2015.02.008.
dc.relation/*ref*/Steinhubl SR. Why have antioxidants failed in clinical trials? Am J Cardiol, 2008;101(10): S14-S19. doi: https://doi.org/10.1016/j.amjcard.2008.02.003.
dc.relation/*ref*/Stephens JW, Khanolkar MP, Bain SC. The biological relevance and measurement of plasma markers of oxidative stress in diabetes and cardiovascular disease. Atheroscl. 2009; 202(2): 321-29. doi: 10.1016/j.atherosclerosis.2008.06.006.
dc.relation/*ref*/Ho E, Galougahi KK, Chia-Chi L, Bhindi R. Biological markers of oxidative stress: Applications to cardiovascular research and practice. Redox Biol. 2013;1: 483-91. doi: 10.1016/j.redox.2013.07.006.
dc.relation/*ref*/Mañon-Rossi W, Garrido G, Nuñez-Selles AJ. Biomarkers of oxidative stress in antioxidant therapy. J Pharm Pharmacogn Res. 2016;4(2): 62-83.
dc.relation/*ref*/Niu Y, DesMarais TL, Tong Z, Yao Y, Costa M. Oxidative stress alters global histone modification and DNA methylation. Free Radic Biol Med. 2015;82: 22-8. doi: https://doi.org/10.1016/j.freeradbiomed.2015.01.028.
dc.relation/*ref*/Firuzi O, Miri R, Tavakkoli M, Saso L. Antioxidant therapy: Current status and future prospects. Curr Med Chem. 2011;18(25): 3871-88. doi: 10.2174/092986711803414368.
dc.relation/*ref*/Tiwari BK, Pandey KB, Abidi AB, Rizvi SI. Markers of oxidative stress during Diabetes Mellitus. J Biomarkers. 2013; 2013: ID 378790. doi: doi.org/10.1155/2013/378790, 8 pp.
dc.relation/*ref*/Frijhoff J, Winyard PG, Zarkovic N, Davies SS, Stocker R, Cheng D, et al. Clinical relevance of biomarkers of oxidative stress. Antioxid Redox Signal. 2015;23(14): 1144-70. doi: https://doi.org/10.1089/ars.2015.6317.
dc.relation/*ref*/Marrocco I, Altieri F, Peluso I. Measurement and clinical significance of biomarkers of oxidative stress in humans. Oxid Med Cell Long. 2017; 2017: ID 6501046. doi: doi.or/10.1155/2017/6501046.
dc.relation/*ref*/Nuñez Selles AJ, Martinez G, Mañon Rossi W. Method for determining Oxidative Stress Index in patients with Diabetes Mellitus and Arterial Hypertension. Oficina Nacional de la Propiedad Industrial (ONAPI), República Dominicana, 2017; P2017-54, 32 pp.
dc.relation/*ref*/Pichardo R, González A, Ramírez W, Escaño F, Jiménez R. Revista Española de Cardiología [Internet]. Revespcardiol.org. 2012 [citado 6 de mayo 2019]. Disponible en: https://tinyurl.com/y5mj4vp7.
dc.relation/*ref*/Organización Panamericana de la Salud. República Dominicana [Internet]. Health in the Americas 2017. 2014 [citado 6 de mayo 2019]. Disponible en: https://tinyurl.com/y4jprc9h.
dc.relation/*ref*/Oficina Nacional de Estadísticas. IX Censo Nacional de Población y Vivienda 2010 (Book, 2012) [WorldCat.org] [Internet]. Worldcat.org. 2012 [citado 6 de mayo 2019]. Disponible en: https://tinyurl.com/y6ps82yb.
dc.relation/*ref*/Grupo de Trabajo para el manejo de la hipertensión arterial de la Sociedad Europea de Hipertensión (ESH) y la Sociedad Europea de Cardiología (ESC). Guía de práctica clínica de la ESH/ESC 2013 para el manejo de la hipertensión arterial [Internet]. Hipertension.cl. 2013 [citado 6 de mayo 2019]. Disponible en: https://tinyurl.com/y52xs3cv.
dc.relation/*ref*/Ozdemirler G, Mehmetcik G, Oztezcan S, Toker G, Sivas A, Uysal M. Peroxidation potential and antioxidant activity of serum in patients with diabetes mellitus and myocardial infarction. Horm Metab Res. 1995;27(4): 194-6.
dc.relation/*ref*/Miller N, Rice-Evans C, Davies MJ. A novel method for measuring antioxidant capacity and its application to monitoring the antioxidant status in premature neonates. Clin Sci. 1993;84(4): 407-12. doi: 10.1042/cs0840407.
dc.relation/*ref*/Ozcan E. A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS cation. Clin Biochem. 2004;37(4): 277-85. doi: https://doi.org/10.1016/j.clinbiochem.2003.11.015
dc.relation/*ref*/Blois M. Antioxidant determinations by the use of a stable free radical. Nature. 1958;181: 1199-00. doi: 10.1038/1811199a0.
dc.relation/*ref*/Esterbauer H, Cheeseman KH, Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. Methods Enzymol. 1990;186: 407-21. doi: https://doi.org/10.1016/0076-6879(90)86134-H.
dc.relation/*ref*/Oliver CN, Ahn B, Moerman EJ, Goldstein S, Stadtman ER. Age related changes in oxidised protein. J Biol Chem. 1987;262(12): 5488-91.
dc.relation/*ref*/Sedlak J, Lindsay RH. Estimation of total protein bond and non-protein sulfhydryl group with Ellman’s reagent. Anal Biochem. 1968;25: 192-205.
dc.relation/*ref*/Del Mestro R, McDonald W. Oxidative enzymes in tissue homogenates. En: Greenwald R, ed., CRC Handbook for Oxygen Radical Research. Boca Raton, Florida: CRC Press; 1985. pp. 291-6.
dc.relation/*ref*/Haining JL, Legan JS. Improved assay for catalase based upon steady-state substrate concentration. Anal Biochem. 1972;45(2): 469-79. doi: https://doi.org/10.1016/0003-2697(72)90209-6.
dc.relation/*ref*/Gil L, Martínez G, González I, Tarinas A, Álvarez A, Giuliani A, et al. Contribution to characterization of oxidative stress in HIV/AIDS patients, Pharmacol Res. 2003; 47(3):217-224. https://doi.org/10.1016/S1043-6618(02)00320-1.
dc.relation/*ref*/Liochev SI. Reactive oxygen species and the free radical theory of aging Free Radic Biol Med. 2013;60:1-4. doi: 10.1016/j.freeradbiomed.
dc.relation/*ref*/Lewis KN, Andziak B, Yang T, Buffenstein R. The naked mole-rat response to oxidative stress: just deal with it. Antioxid. Redox Signal. 2013;19(12): 1388-99. doi:10.1089/ars.2012.4911.
dc.relation/*ref*/Holzerová E, Prokisch H. Mitochondria: Much ado about nothing? How dangerous is reactive oxygen species production? Int J Biochem Cell Biol. 2015;63: 16-20. doi: 10.1016/j.biocel.2015.01.021.
dc.relation/*ref*/Sas K, Szabó E, Vécsei L. Mitochondria, Oxidative Stress and the Kynurenine System, with a Focus on Ageing and Neuroprotection. Molecules. 2018;23(1). pii: E191. doi: 10.3390/molecules23010191.
dc.relation/*ref*/Tan J, Xu X, Tong Z, Yu Q, Lin Y, Kuang W. Decreased osteogenesis of adult mesenchymal stem cells by reactive oxygen species under cyclic stretch: a possible mechanism of age related osteoporosis. Bone Res. 2015;3: ID 15003. doi: 10.1038/boneres.2015.3.
dc.relation/*ref*/Nita M, Grzybowski A. The role of the reactive oxygen species and oxidative stress in the pathomechanism of the age-related ocular diseases and other pathologies of the anterior and posterior eye segments in adults. Oxid Med Cell Longev. 2016;2016: ID 3164734. doi: 10.1155/2016/3164734.
dc.relation/*ref*/Birch‐Machin MA, Bowman A. Oxidative stress and ageing. Br J Dermatol. 2016 Oct;175 Suppl 2: 26-9. doi: 10.1111/bjd.14906.
dc.relation/*ref*/Block G, Dietrich M, Norkus EP, Morrow JD, Hudes M, Caan B, Packer L. Factors associated with oxidative stress in human populations. Am J Epidemiol. 2002;156(3): 274-85.
dc.relation/*ref*/Leszek J, E Barreto G, Gasiorowski K, Koutsouraki E, Aliev G. Inflammatory mechanisms and oxidative stress as key factors responsible for progression of neurodegeneration: role of brain innate immune system. CNS Neurol Disord Drug Targets. 2016;15(3): 329-36.
dc.relation/*ref*/Ezzati M. Methodology for assessment of environmental burden of disease – Annex 4.1 [Internet]. Who.int. 2010 [citado 7 de mayo 2019]. Disponible en: https://tinyurl.com/y6c4pkb3.
dc.relation/*ref*/Leung AA, Daskalopoulou SS, Dasgupta K, McBrien K, Butalia S, Zarnke KB, et al. Hypertension Canada's 2017 guidelines for diagnosis, risk assessment, prevention, and treatment of hypertension in adults. Can J Cardiol. 2017;33(5): 557-76. doi: https://doi.org/10.1016/j.cjca.2017.03.005.
dc.relation/*ref*/Tran MT, Mitchell TM, Kennedy DT, Giles JT. Role of coenzyme Q10 in chronic heart failure, angina, and hypertension. Pharmacotherapy. 2001;21(7): 797-806. 57. Mrowka R. Recent Advances in Hypertension Research. Acta Physiol (Oxf). 2019;8: e13295. doi: 10.1111/apha.13295.
dc.relation/*ref*/Kintscher U. The burden of hypertension. EuroIntervention. 2013;9 (Suppl R): R12-15. doi: 10.4244/EIJV9SRA3.
dc.relation/*ref*/Yao EH, Fukuda N, Matsumoto T, Kobayashi N, Katakawa M, Yamamoto C, et al. Losartan improves the impaired function of endothelial progenitor cells in hypertension via an antioxidant effect. Hypertens Res. 2007;30(11): 1119-28. doi: 10.1291/hypres.30.1119.
dc.relation/*ref*/Profumo E, Buttari B, Saso L, Rigano R. Pleiotropic effects of statins in atherosclerotic disease: focus on the antioxidant activity of atorvastatin. Curr Top Med Chem. 2014;14(22): 2542-51. doi: 10.2174/1568026614666141203130324.
dc.relation/*ref*/Simic DV, Mimic-Oka J, Pljesa-Ercegovac M, Savic-Radojevic A, Opacic M, Matic D, Simic T. Byproducts of oxidative protein damage and antioxidant enzyme activities in plasma of patients with different degrees of essential hypertension. J Hum Hypertens. 2006;20(2): 149-55. doi: https://doi.org/10.1038/sj.jhh.1001945.
dc.relation/*ref*/Touyz RM, Schiffrin EL. Reactive oxygen species in vascular biology: implications in hypertension. Histochem Cell Biol. 2004;122(4): 339-52. doi: https://doi.org/10.1007/s00418-004-0696-7.
dc.relation/*ref*/Duffy SJ, Gokce N, Holbrook M, Huang A, Frei B, Keaney JF, Vita JA. Treatment of hypertension with ascorbic acid. Lancet. 1999;354(9195): 2048-9. doi: https://doi.org/10.1016/S0140-6736(99)04410-4.
dc.relation/*ref*/Fotherby MD, Williams JC, Forster LA, Craner P, Ferns GA. Effect of vitamin C on ambulatory blood pressure and plasma lipids in older persons. J Hypertens. 2000;18(4): 411-5.
dc.relation/*ref*/Juraschek SP, Guallar E, Appel LJ, Miller ER 3rd. Effects of vitamin C supplementation on blood pressure: a meta-analysis of randomized controlled trials. Am J Clin Nutr. 2012;95(5): 1079-88. doi:10.3945/ajcn.111.027995.
dc.relation/*ref*/Heart Protection Study Collaborative Group: MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: A randomised placebo-controlled trial. Lancet. 2002;360(9326): 23-33. doi: 10.1016/S0140-6736(02)09328-5.
dc.relation/*ref*/Kim MK, Sasaki S, Sasazuki S, Okubo S, Hayashi M, Tsugane S. Lack of long-term effect of vitamin C supplementation on blood pressure. Hypertension. 2002;40(6): 797-803.
dc.relation/*ref*/Palumbo G, Avanzini F, Alli C, Roncaglioni MC, Ronchi E, Cristofari M, et al. Effects of vitamin E on clinic and ambulatory blood pressure in treated hypertensive patients: Collaborative Group of the Primary Prevention Project (PPP) Hypertension Study. Am J Hypertens. 2000;13(5 Pt 1): 564-7.
dc.relation/*ref*/Münzel T, Gori T, Bruno RM, Taddei S. Is oxidative stress a therapeutic target in cardiovascular disease? Eur Heart J. 2010 Nov;31(22): 2741-8. doi: 10.1093/eurheartj/ehq396.
dc.relation/*ref*/Heart Outcomes Prevention Evaluation Study Investigators, Yusuf S, Sleight P, Pogue J, Bosch J, Davies R, Dagenais G. Effects of an angiotensin-converting-enzyme, ramipril, on cardiovascular events in high-risk patients. N Engl J Med. 2000;342(3): 145-53. doi: 10.1056/NEJM200001203420301.
dc.relation/*ref*/Head GA, Shaw JE, Dunstan DW, Owen N, Magliano DJ, Chadban S, Zimmet P. Hypertension, white-coat hypertension and masked hypertension in Australia: findings from the Australian Diabetes, Obesity, and Lifestyle Study 3. J Hypertens; 2019. doi: 10.1097/HJH.0000000000002087. [Ahead of print].
dc.relation/*ref*/Schulz E, Gori T, Münzel T. Oxidative stress and endothelial dysfunction in hypertension. Hypertens Res. 2011;34(6): 665-73. doi: https://doi.org/10.1038/hr.2011.39.
dc.relation/*ref*/Dikalova AE, Itani HA, Nazarewicz RR, McMaster WG, Flynn CR, Uzhachenko R, et al. Sirt3 Impairment and SOD2 Hyperacetylation in Vascular Oxidative Stress and Hypertension. Circ Res. 2017;121(5): 564-74. doi:10.1161/CIRCRESAHA.117.310933.
dc.relation/*ref*/Haidara MA, Yassin HZ, Rateb M, Ammar H, Zorkani MA. Role of oxidative stress in development of cardiovascular complications in diabetes mellitus. Curr Vasc Pharmacol. 2006;4(3): 215-27. doi: https://doi.org/10.2174/157016106777698469.
dc.relation/*ref*/Kodavanti UP, Schladweiler MC, Ledbetter AD, Watkinson WP, Campen MJ, Winsett DW, et al. The spontaneously hypertensive rat as a model of human cardiovascular disease: evidence of exacerbated cardiopulmonary injury and oxidative stress from inhaled emission particulate matter. Toxicol Appl Pharmacol. 2000;164(3): 250-63. doi: https://doi.org/10.1006/taap.2000.8899.
dc.relation/*ref*/Testa R, Bonfigli AR, Genovese S, De Nigris V, Ceriello, A. The possible role of flavonoids in the prevention of diabetic complications. Nutrients. 2016;8(5). pii: E310. doi: 10.3390/nu8050310.
dc.relation/*ref*/Tanveer A, Akram K, Farooq U, Hayat Z, Shafi A. Management of diabetic complications through fruit flavonoids as a natural remedy. Crit Rev Food Sci Nutr. 2017;57(7): 1411-22. doi: 10.1080/10408398.2014.1000482.
dc.rightsDerechos de autor 2019 Ciencia y Saludes-ES
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/4.0es-ES
dc.sourceScience and Health; Vol 3 No 2 (2019): Science and Health, may-August; 17-33en-US
dc.sourceCiencia y Salud; Vol. 3 Núm. 2 (2019): Ciencia y Salud, mayo-agosto; 17-33es-ES
dc.source2613-8824
dc.source2613-8816
dc.source10.22206/cysa.2019.v3i2
dc.subjectOxidative stress indexen-US
dc.subjectredox biomarkersen-US
dc.subjectoxidative damageen-US
dc.subjectantioxidant therapyen-US
dc.subjecthypertensionen-US
dc.subjectíndice de estrés oxidativoes-ES
dc.subjectbiomarcadores de redoxes-ES
dc.subjectdaño oxidativoes-ES
dc.subjectterapia antioxidantees-ES
dc.subjecthipertensiónes-ES
dc.titleCorrelation between the arterial hypertension degree and oxidative stress index. Cohort study in a population of systemic hypertensive patients in Dominican Republicen-US
dc.titleCorrelación entre el grado de hipertensión arterial y el índice de estrés oxidativo. Estudio de cohorte en una población de pacientes hipertensos sistémicos en República Dominicanaes-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
Files
Collections
Articulos CS