Síndrome de Turner y embarazo espontáneo: presentación de dos casos
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Date
Subject
Turner Syndrome
complete monosomy
spontaneous pregnancy
Síndrome de Turner
monosomía completa
embarazo espontáneo
complete monosomy
spontaneous pregnancy
Síndrome de Turner
monosomía completa
embarazo espontáneo
Language:
Journal Title
Journal ISSN
Volume Title
Publisher
Intituto Tecnológico de Santo Domingo (INTEC)
Introducción: El Síndrome de Turner constituye la única monosomía completa compatible con la vida. Se produce por la no disyunción meiótica o mitótica de los cromosomas, con expresión variable, que se presenta en el sexo femenino y en el que es extraordinariamente infrecuente el embarazo espontáneo.
Objetivo: Describir dos casos clínicos con diagnóstico de Síndrome de Turner que lograron embarazo espontáneo.
Presentación de los casos clínicos:
Caso 1: Paciente femenina que a los 9 años de edad cronológica es remitida al Departamento de Endocrinología Pediátrica del Instituto Nacional de Endocrinología, por presentar retraso del crecimiento y desarrollo, donde a través de las manifestaciones clínicas y de los exámenes complementarios realizados, se le diagnosticó un Síndrome de Turner 45X/46XX. Recibió tratamiento con hormona de crecimiento biosintética y hormonas sexuales; logrando embarazo espontáneo a los 23 años de edad, y actualmente, tiene una hija de un año y medio.
Caso 2: Paciente femenina que a los de 9.4 años de edad cronológica es remitida al Departamento de Endocrinología Pediátrica del Instituto Nacional de Endocrinología por presentar retraso del crecimiento y desarrollo, donde a través de las manifestaciones clínicas y de los exámenes complementarios realizados, se le diagnosticó un Síndrome de Turner 45X. Recibió tratamiento con hormona de crecimiento biosintética, presentó menarquía espontánea a los 13 años con ciclos menstruales regulares; logró gestación espontánea a los 20 años, interrumpiendo el mismo por decisión personal.
Conclusiones: El embarazo en el Síndrome de Turner es infrecuente. Existe solo una publicación nacional, y muy pocas internacionales, de pacientes con esta afección que logren gestación espontánea. Se plantea que puede existir una línea celular a nivel de ovarios y útero que permite el desarrollo folicular y así lograr la fecundación. En la actualidad las expectativas de fertilidad con este síndrome han cambiado en los últimos años, gracias a los tratamientos de reproducción asistida.
Introduction:Turner Syndrome is the only complete monosomy compatible with life. It is disjunction of chromosomes, with variable expression, it occurs in the female sex and it is extraordinarily uncommon in spontaneous pregnancy in this patient. Objective: To describe two clinical cases with diagnosis of Turner Syndrome that achieved spontaneous pregnancy. Presentation of clinical cases: Case1: A female patient who, at 9 years of age, is referred to the Department of Pediatric Endocrinology of the National Institute of Endocrinology for delayed growth and development, where through the clinical manifestations and complementary examinations performed, she was diagnosed with Turner Syndrome 45X/46XX. She was treated with biosynthetic growth hormone and sex hormones; who achieved spontaneous pregnancy at age 23 and currently has a daughter a year and a half. Case2: A female patient who is chronologically 9,4 years of age is referred to the Department of Pediatric Endocrinology of the National Institute of Endocrinology because of the delay in growth and development where, through clinical manifestations and complementary examinations, she was diagnosed with Turner Syndrome 45X. Received treatment with biosynthetic growth hormone, presented spontaneous menarche at 13 years with regular menstrual cycles; spontaneous gestation al 20 years interrupting the same by personal decision. Conclusions: Pregnancy in Turner´s Syndrome is not frequent. There is one national and very few international publications of patients with this condition that achieve spontaneous gestation. It is suggested that there may be a cell line at the level of ovaries and uterus that allows follicular development and this archive fertilization. At presents, the expectation of fertility with this syndrome has changed in the last year, thanks to the treatments of assisted reproduction.
Introduction:Turner Syndrome is the only complete monosomy compatible with life. It is disjunction of chromosomes, with variable expression, it occurs in the female sex and it is extraordinarily uncommon in spontaneous pregnancy in this patient. Objective: To describe two clinical cases with diagnosis of Turner Syndrome that achieved spontaneous pregnancy. Presentation of clinical cases: Case1: A female patient who, at 9 years of age, is referred to the Department of Pediatric Endocrinology of the National Institute of Endocrinology for delayed growth and development, where through the clinical manifestations and complementary examinations performed, she was diagnosed with Turner Syndrome 45X/46XX. She was treated with biosynthetic growth hormone and sex hormones; who achieved spontaneous pregnancy at age 23 and currently has a daughter a year and a half. Case2: A female patient who is chronologically 9,4 years of age is referred to the Department of Pediatric Endocrinology of the National Institute of Endocrinology because of the delay in growth and development where, through clinical manifestations and complementary examinations, she was diagnosed with Turner Syndrome 45X. Received treatment with biosynthetic growth hormone, presented spontaneous menarche at 13 years with regular menstrual cycles; spontaneous gestation al 20 years interrupting the same by personal decision. Conclusions: Pregnancy in Turner´s Syndrome is not frequent. There is one national and very few international publications of patients with this condition that achieve spontaneous gestation. It is suggested that there may be a cell line at the level of ovaries and uterus that allows follicular development and this archive fertilization. At presents, the expectation of fertility with this syndrome has changed in the last year, thanks to the treatments of assisted reproduction.
Description
Type
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/publishedVersion
Source
Science and Health; Vol 2 No 3 (2018): Science and Health, september-december; 35-40
Ciencia y Salud; Vol. 2 Núm. 3 (2018): Ciencia y Salud, septiembre-diciembre; 35-40
2613-8824
2613-8816
10.22206/cysa.2018.v2i3
Ciencia y Salud; Vol. 2 Núm. 3 (2018): Ciencia y Salud, septiembre-diciembre; 35-40
2613-8824
2613-8816
10.22206/cysa.2018.v2i3